- 08 oktober 2014
Bratislava Medical Journal. 2014;115(5):260-6.
RESULTS: Altered behavioral performances were found in RF-EMR-exposed rats. Additionally, elevated TBARS level was found with all brain regions studied. RF-EMR exposure significantly decreased TA in the amygdala and cerebellum but its level was not significantly changed in other brain regions. GST activity was significantly decreased in the hippocampus but, its activity was unaltered in other brain regions studied.
CONCLUSION: RF-EMR exposure for a month induced oxidative stress in rat brain, but its magnitude was different in different regions studied. RF-EMR-induced oxidative stress could be one of the underlying causes for the behavioral deficits seen in rats after RF-EMR exposure (Fig. 5, Ref. 37).
PubMed - "Microwaves have been suggested to induce neuronal injury and increase permeability of the blood-brain barrier (BBB), but the mechanism remains unknown. The role of the vascular endothelial growth factor (VEGF)/Flk-1-Raf/MAPK kinase (MEK)/extracellular-regulated protein kinase (ERK) pathway in structural and functional injury of the blood-brain barrier (BBB) following microwave exposure was examined."
" (...) results indicated that the structure of the BBB was damaged and the permeability of ions and low-molecular-weight molecules was increased."
Abstract - Myelin provides the electrical insulation for the central and peripheral nervous system and develops rapidly in the first years of life, but continues into mid-life or later. Myelin integrity is vital to healthy nervous system development and functioning. This review outlines the development of myelin through life, and then considers the evidence for an association between myelin integrity and exposure to low-intensity radiofrequency electromagnetic fields (RF-EMFs) typical in the modern world. In RF-EMF peer-reviewed literature examining relevant impacts such as myelin sheath, multiple sclerosis, and other myelin-related diseases, cellular examination was included.
There are surprisingly little data available in each area, but considered together a picture begins to emerge in RF-EMF-exposed cases: (1) significant morphological lesions in the myelin sheath of rats; (2) a greater risk of multiple sclerosis in a study subgroup; (3) effects in proteins related to myelin production; and (4) physical symptoms in individuals with functional impairment electrohypersensitivity, many of which are the same as if myelin were affected by RF-EMF exposure, giving rise to symptoms of demyelination. In the latter, there are exceptions; headache is common only in electrohypersensitivity, while ataxia is typical of demyelination but infrequently found in the former group. Overall, evidence from in vivo and in vitro and epidemiological studies suggests an association between RF-EMF exposure and either myelin deterioration or a direct impact on neuronal conduction, which may account for many electrohypersensitivity symptoms.
Uit de abstract: "The observed protein expression changes may be related to brain plasticity alterations, indicative of oxidative stress in the nervous system or involved in apoptosis and might potentially explain human health hazards reported so far, such as headaches, sleep disturbance, fatigue, memory deficits, and brain tumor long-term induction under similar exposure conditions."
spectroscopynow.com - The controversy over the potential health effects of electromagnetic radiation associated with cell phones has been fuelled by new research originating in Iran. A team of scientists from Shiraz University has found that electromagnetic fields change the proteome of rat testes, with implications for fertility.
There has been conflicting evidence over the last decade on the harmful nature of these EMFs. For instance, some studies have suggested that they do not affect the brain whereas others have found the opposite. Most notably, a recent study from Greece revealed that 143 proteins in the mouse brain were affected, including some from the regions dealing with learning and memory. The same type of radiation is emitted by wireless transmitters and wireless computer equipment, so the effects might be more widespread than first anticipated.
Now, Masood Sepehrimanesh, Nasrin Kazemipour, Mehdi Saeb and Saeed Nazifi have turned their attention to the testis, comparing the protein expressions from animals exposed to an EMF with those that were not exposed. Their main focus was on proteins that were induced or completely inhibited, rather than those which underwent a partial change in expression.
Lack of confirmation of symptoms attributed to electromagnetic fields (EMF) and triggered by EMF exposure has highlighted the role of individual factors. Prior observations indicate intolerance to other types of environmental exposures among persons with electromagnetic hypersensitivity (EHS). This study assessed differences in odor and noise intolerance between persons with EHS and healthy controls by use of subscales and global measures of the Chemical Sensitivity Scale (CSS) and the Noise Sensitivity Scale (NSS). The EHS group scored significantly higher than the controls on all CSS and NSS scales. Correlation coefficients between CSS and NSS scores ranged from 0.60 to 0.65 across measures. The findings suggest an association between EHS and odor and noise intolerance, encouraging further investigation of individual factors for understanding EMF-related symptoms.
Open Access: http://bit.ly/1rEMZwx
Samenvatting op de webpagina van de European Journal of Cancer.
Samenvatting van de studie op PubMed. De auteurs menen dat mogelijk een omgevingsfactor aan de basis ligt van de stijging.
Frontal & temporal lobe gliobastoma incidence increased in the US from 1992-2006
Zada et al. Incidence trends in the anatomic location of primary malignant brain tumors in the United States: 1992-2006. World Neurosurg. 2012 Mar-Apr;77(3-4):518-24.
"CONCLUSIONS: Data from 3 major cancer registries demonstrate increased incidences of GBMs in the frontal lobe, temporal lobe, and cerebellum, despite decreased incidences in other brain regions. Although this may represent an effect of diagnostic bias, the incidence of both large and small tumors increased in these regions. The cause of these observed trends is unknown."
"Although these results may represent an effect of diagnostic bias or refinements in anatomical subsite coding, an environmental cause of the increases of high grade frontal and temporal lobe malignancies cannot be ruled out. Further studies are indicated to establish whether a correlation with environmental factors exists." (p. 524)
Abstract - One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms—two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields.
(...) The idea that some individuals are more sensitive to the electromagnetic field than others, due to genetic background or/and current health status, appears very attractive and should be a subject of further studies.
"This classic paper by W. Ross Adey, M.D., one of the pioneers in microwave radiation health effects research, was published in 1979. Many years before ICNIRP adopted thermal-based regulatory standards, we knew that non-thermal levels of microwave radiation had significant effects on the brain. Our government chose to ignore this research."
Open access paper (PDF)